Micromyx offers microbiology laboratory services integral to the discovery, development, and registration of new antimicrobial agents. Micromyx scientists have a broad range of technical expertise in antimicrobial research and development from discovery all the way through the regulatory submission and review process. The microbiological assays and expertise offered by Micromyx have a proven track record in that they have been utilized successfully by its employees to gain FDA approval of multiple classes of antibiotics. Companies that are engaged in anti-infective research but lack the full complement of microbiological expertise and resources in-house that are required to drive the entire antibiotic discovery/development process can benefit from the microbiological assay services offered by Micromyx. In addition, we can provide standard and/or custom assays to suit the customer's needs.

Partial List of Microbiology Services

• Microbial identification (Biochemical or 16S rRNA)
• Compound library and combinatorial library screening
• Spectrum/potency assessments
• Minimal Inhibitory Concentration (MIC) assay
• Minimal Bactericidal Concentration (MBC) assay
• Time-kill kinetic assays
• Microbial quantitation
• Resistance development/mutant selection
• PCR detection of resistant genes
• Assessment of serum protein effect on antimicrobial activity

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Micromyx offers biochemistry and molecular biology services to support the discovery, evaluation, and confirmation of antimicrobial agents. Micromyx scientists are experienced in target based antibiotic discovery as well as elucidating the mechanism of action of unique antibacterial compounds. Whether a company needs to augment their internal screening effort or seeks to answer critical questions regarding a compound’s mechanistic target, Micromyx has the experience to design and implement a research plan.

Partial List of Biochemistry & Molecular Biology Services

• Cloning and expression of novel targets for antibiotic discovery
• Purification of enzyme targets
• Optimization of enzyme assays for inhibitor screening
• Screening compounds for enzyme inhibition
• Kinetic characterization of “hits” from enzyme inhibition screens
• Determining the mechanism of action of novel antimicrobial agents

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Micromyx was founded by senior scientists from the former Pharmacia Corporation, Dean Shinabarger and Gary Zurenko. These two individuals have extensive experience in the entire drug discovery and development process, from target identification to new drug registration.

Micromyx offers consulting services for all areas of antimicrobial discovery and development. Our broad range of experience will allow us to provide valuable advice to the client from early evaluation of compounds through advanced preclinical testing and registration. Medical writing services for antimicrobial agent regulatory documents is available. Custom consulting contracts can be created for per diem or longer-term arrangements.

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© Micromyx 2008